Analytical Data
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基因名
RUVBL2
- Application
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别名
RUVBL2；INO80H；NMP238；TIP49；RuvB-like 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y230
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表达区间
2-463aa
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氨基酸序列
ATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVLEMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALTQAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTTPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS
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分子量
67.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RUVBL2, a member of the RuvB-like protein family, plays a crucial role in various cellular processes, including DNA repair, transcription regulation, and chromatin remodeling. Its significance has attracted considerable attention in the fields of cancer biology and molecular genetics due to its overexpression in several tumor types and its involvement in oncogenic processes. Research has demonstrated that RUVBL2 acts as a cofactor for various transcription factors and is implicated in the assembly of chromatin remodeling complexes, influencing gene expression and cellular proliferation. Additionally, studies have linked RUVBL2 to the regulation of key oncogenic pathways, such as the c-Myc and Wnt signaling pathways, further highlighting its potential as a therapeutic target. The recombinant expression of RUVBL2 allows for detailed investigation of its biochemical properties, structural characteristics, and functional roles in cellular mechanisms. Understanding RUVBL2's interactions and regulatory mechanisms at a molecular level is vital for uncovering its contribution to tumorigenesis and developing targeted therapies. Moreover, the development of specific inhibitors against RUVBL2 is an emerging area of research, aiming to exploit its critical function in cancer progression and improve therapeutic outcomes. Overall, the study of RUVBL2 in the context of recombinant protein research not only enhances our understanding of fundamental cellular processes but also paves the way for innovation in cancer treatment strategies.
