Analytical Data
-
Gene name
CCR6
- Application
-
Alternative Names
CCR6；CKRL3；CMKBR6；GPR29；C-C chemokine receptor type 6
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P51684
-
Expression Region
1-374aa
-
AA Sequence
MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVP IAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLP FWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQA TKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPK YQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRH KAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTV TEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAG RYSENISRQTSETADNDNASSFTM
-
Molecular Weight
47 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CCR6 (C-C chemokine receptor type 6) is a critical chemokine receptor predominantly expressed on various immune cells, including T helper 17 (Th17) cells and dendritic cells. It plays a vital role in immune responses, particularly in guiding these cells to sites of inflammation and infection. Given its significant involvement in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, as well as its relevance in cancer immunology, CCR6 has become a focal point of research. The study of CCR6 and its ligands, particularly CCL20, provides insights into the mechanisms of immune cell trafficking and the regulation of inflammatory responses. The recombinant expression of CCR6 protein allows for the characterization of its structure and function, enabling the development of therapeutic strategies aimed at modulating its activity. This research not only contributes to our understanding of immune cell dynamics but also presents potential avenues for targeted therapies in diseases characterized by aberrant CCR6 signaling. Consequently, investigating CCR6 recombinant proteins advances both basic immunology and the development of innovative treatment modalities.
