Analytical Data
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Gene name
COX5A
- Application
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Alternative Names
COX5A;Cytochrome c oxidase subunit 5A. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20674
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Expression Region
42-150aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSSHGSQET DEEFDARWVT YFNKPDIDAW ELRKGINTLV TYDMVPEPKI IDAALRACRR LNDFASTVRI LEVVKDKAGP HKEIYPYVIQ ELRPTLNELG ISTPEELGLD KV
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Molecular Weight
15 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COX5A, a vital subunit of cytochrome c oxidase (CCO), plays a crucial role in mitochondrial respiration and energy production. As a component of the oxidative phosphorylation pathway, COX5A contributes significantly to the conversion of mitochondrial energy into adenosine triphosphate (ATP). Research into COX5A has gained momentum due to its implications in various metabolic disorders and mitochondrial diseases. Mutations or deficiencies in COX5A can lead to impaired ATP synthesis, resulting in cellular dysfunction and contributing to conditions such as myopathies and neurodegenerative diseases. Additionally, COX5A's structure and function are of interest in cancer research, as alterations in mitochondrial metabolism are frequently observed in tumors. Recombinant expression of COX5A provides a valuable tool for studying its biochemical properties, regulation, and interactions with other mitochondrial components, as well as for developing potential therapeutic strategies. The study of COX5A and its recombinant protein offers insights into mitochondrial dynamics and helps advance our understanding of energy metabolism in health and disease, making it an essential focus of contemporary biomedical research.
