Analytical Data
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基因名
CCR4
- Application
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别名
CCR4；CMKBR4；C-C chemokine receptor type 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51679
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表达区间
1-360aa
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氨基酸序列
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVF VFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAA DQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRART LTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKV LSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVL FLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQS TMDHDLHDAL
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分子量
43 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCR4 (C-C chemokine receptor type 4) is a G protein-coupled receptor that plays a crucial role in immune system regulation, particularly in the migration and differentiation of T cells. It is primarily expressed in lymphocytes and is involved in directing the migration of these immune cells to sites of inflammation, thereby playing a significant role in various immune responses. Recent studies have highlighted CCR4's involvement not only in normal immune function but also in pathological conditions such as allergies, autoimmune diseases, and cancer. For instance, CCR4 is known to be highly expressed in certain types of tumors, correlating with poor prognosis and disease progression, making it an attractive target for immunotherapy. The development of CCR4-recombinant proteins allows researchers to better understand its biochemical pathways and interactions, aiding the design of targeted therapies and monoclonal antibodies. By studying these recombinant proteins, scientists aim to delineate the precise mechanisms through which CCR4 influences immune cell behavior and disease outcomes. This research is pivotal for advancing therapeutic strategies aimed at modulating immune responses in various clinical contexts, particularly in oncology and chronic inflammatory diseases. Thus, CCR4 and its recombinant forms are at the forefront of investigations that could lead to novel treatments and improved patient outcomes.
