Analytical Data
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Gene name
HVCN1
- Application
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Alternative Names
HVCN1；VSOP；Voltage-gated hydrogen channel 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96D96
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Expression Region
1-273aa
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AA Sequence
MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN
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Molecular Weight
31.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HVCN1, or Hydrogen Voltage-gated Channel 1, is a protein initially identified for its role in the regulation of intra- and extracellular pH levels through its voltage-dependent channel activity. Research has shown that HVCN1 is notably expressed in various immune cells, particularly in neutrophils and B cells, where it contributes to immune responses such as reactive oxygen species (ROS) generation. The interest in HVCN1 has significantly increased due to its potential implications in autoimmune diseases and cancer, as it influences cell proliferation and apoptosis. Additionally, its unique function as a proton channel has led scientists to investigate HVCN1 as a therapeutic target. Recent studies have utilized recombinant HVCN1 proteins to elucidate its structure-function relationship, paving the way for novel medical applications. Understanding the mechanisms underlying HVCN1’s role in immune modulation and its involvement in pathological conditions may offer new insights into innovative treatment approaches for diseases where immune dysregulation is a key factor. As such, the ongoing research into HVCN1 recombinant proteins not only enhances our fundamental knowledge of ion channel biology but also holds promise for the development of targeted therapies aimed at improving patient outcomes.
