Analytical Data
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基因名
GRO-gamma/CXCL3
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简介
The GRO-gama/CXCL3 Protein, acting as a CXCR2 ligand, induces chemotactic activity for neutrophils. It potentially influences inflammation through autocrine effects on endothelial cells. In vitro studies highlight the processed form GRO-gamma(5-73)'s fivefold increase in chemotactic activity for neutrophilic granulocytes, indicating a potential regulatory mechanism for neutrophil recruitment and function. GRO-gamma/CXCL3 Protein, Human (HEK293, Fc) is the recombinant human-derived GRO-gamma/CXCL3 protein, expressed by HEK293, with N-hFc labeled tag.
- Application
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别名
rHuGRO-γ/CXCL3; C-X-C motif chemokine 3; MIP2-beta
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种属
Human
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表达系统
HEK293
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标签
N-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P19876
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表达区间
A35-N107
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蛋白长度
Partial
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分子量
38-41 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRO-gamma, also known as CXCL3, is a chemokine belonging to the CXC subfamily of chemokines, which plays a critical role in immune responses and inflammation. It is primarily involved in the recruitment of neutrophils and other immune cells to sites of infection or injury. Research has shown that GRO-gamma not only influences the migration of various immune cell types but also participates in tumor progression and metastasis. Elevated levels of CXCL3 have been observed in several types of cancers, indicating its potential role in promoting tumor microenvironmental changes that facilitate cancer cell survival and dissemination. Consequently, understanding the molecular mechanisms underlying GRO-gamma/CXCL3's function can provide insights into its therapeutic potential as a target for cancer treatment, as well as its involvement in inflammatory diseases. The recombinant protein form of GRO-gamma/CXCL3 has been utilized in various studies to elucidate its biological activity and interactions with its receptors. These studies have highlighted its importance in modulating immune responses and may pave the way for the development of novel therapeutic strategies aimed at manipulating its pathways to improve patient outcomes in autoimmune diseases and cancer therapies. Thus, ongoing research into GRO-gamma/CXCL3 continues to unveil its complex roles in pathophysiological processes, making it a significant focus in the fields of immunology and oncology.
