Analytical Data
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Gene name
PIK3R5
- Application
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Alternative Names
PI3-kinase p101 subunitPhosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit ;PtdIns-3-kinase regulatory subunitProtein FOAP-2;PtdIns-3-kinase p101p101-PI3K
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WYR1
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Expression Region
1-494aa
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Molecular Weight
70.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The PIK3R5 gene encodes the p85β regulatory subunit of phosphoinositide 3-kinase (PI3K), an essential enzyme involved in various cellular processes such as growth, proliferation, and survival. Research into PIK3R5 has gained significant attention due to its role in oncogenesis and various diseases, including cancer. The overactivation or dysregulation of the PI3K signaling pathway, in which PIK3R5 plays a crucial role, is frequently observed in tumors, leading to enhanced cell survival and proliferation. Understanding the biochemical properties and functional mechanisms of PIK3R5 is critical for elucidating its involvement in these pathological conditions. Recombining PIK3R5 into a protein allows for detailed studies, including the assessment of its interactions with other signaling molecules and its impact on cellular signaling pathways. The production of recombinant PIK3R5 also facilitates the development of targeted therapies by enabling the screening of small molecules or biological agents that can modulate PI3K activity. Additionally, elucidating the structural characteristics of the PIK3R5 protein through techniques like X-ray crystallography or NMR spectroscopy could reveal insights into its regulatory function, offering potential avenues for novel therapeutic interventions in diseases associated with PI3K signaling dysregulation. Overall, the study of recombinant PIK3R5 serves as a foundation for advancing our understanding of its role in health and disease, highlighting its potential as a therapeutic target and biomarker in cancer and other related disorders.
