Analytical Data
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基因名
CHMP6
- Application
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别名
CHMP6；VPS20；Charged multivesicular body Protein 6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96FZ7
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表达区间
1-201aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSHMGNLFG RKKQSRVTEQ DKAILQLKQQ RDKLRQYQKR IAQQLERERA LARQLLRDGR KERAKLLLKK KRYQEQLLDR TENQISSLEA MVQSIEFTQI EMKVMEGLQF GNECLNKMHQ VMSIEEVERI LDETQEAVEY QRQIDELLAG SFTQEDEDAI LEELSAITQE QIELPEVPSE PLPEKIPENV PVKARPRQAE LVAAS
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHMP6, a key component of the endosomal sorting complex required for transport (ESCRT), has garnered attention in the field of cell biology due to its crucial role in various cellular processes, including multivesicular body (MVB) formation, membrane repair, and the regulation of receptor degradation. As a member of the ESCRT-III complex, CHMP6 participates in the sorting and trafficking of ubiquitinated membrane proteins, influencing processes such as viral budding and cytokinesis. The study of CHMP6 recombinant protein is significant for understanding its structure-function relationships and the molecular mechanisms underlying its involvement in pathological conditions, including cancer and viral infections. Additionally, CHMP6 has shown potential as a therapeutic target, highlighting the need for in-depth investigations into its biochemical properties and interactions. Recombinant protein studies enable the exploration of CHMP6's functional roles in vitro and offer insights into its potential as a biomarker or therapeutic candidate, paving the way for novel strategies in disease intervention and treatment.
