Analytical Data
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基因名
CYP3A43
- Application
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HB55
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表达区间
1-393aa
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分子量
52.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CYP3A43 is a member of the cytochrome P450 family of enzymes, primarily involved in the metabolism of a wide range of endogenous and exogenous compounds, including drugs and steroids. The interest in CYP3A43 has grown due to its potential role in pharmacogenetics, as variations in its gene can influence drug metabolism and response, potentially leading to adverse drug reactions or therapeutic failures. Unlike its more extensively studied relatives CYP3A4 and CYP3A5, CYP3A43 exhibits unique substrate specificity and expression patterns, which may critically impact individual drug clearance. Recent studies suggest that CYP3A43 may be involved in the metabolic activation of certain prodrugs, highlighting its importance in drug development and personalized medicine. Additionally, investigations into its structure and function provide insights into the complex regulation of the cytochrome P450 enzyme system. Understanding the functional characteristics and polymorphic variants of CYP3A43 could lead to improved dosing strategies and safer therapeutic options for patients, making it a significant target for ongoing research.
