Analytical Data
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基因名
cia
- Application
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种属
Escherichia coli
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P06716
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表达区间
282-385aa
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分子量
15.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cyclic AMP (cAMP) is a critical second messenger that plays a pivotal role in various cellular processes, including energy metabolism, gene expression, and cell signaling. The regulation of cAMP levels is essential for maintaining cellular homeostasis and is often disrupted in various diseases, including cancer and heart conditions. One of the key enzymes involved in cAMP metabolism is phosphodiesterase (PDE), which hydrolyzes cAMP to AMP, thereby terminating its signaling effects. The study of cyclic AMP signal transduction has led to significant advancements in understanding how cells communicate and respond to external stimuli. Researchers have focused on the development and characterization of cyclic AMP-related proteins, such as cAMP-dependent protein kinases (PKA) and exchange proteins activated by cAMP (Epac), as these proteins mediate the diverse physiological effects of cAMP. The reconstitution of these proteins in vitro allows scientists to dissect their structural and functional properties, elucidating how cAMP modulates various signaling pathways. Additionally, investigating the interactions between cAMP and its effector proteins has implications for therapeutic interventions, particularly in targeting diseases associated with aberrant cAMP signaling. Therefore, the study of cAMP-related proteins is not only fundamental to basic biological research but also holds great promise for developing novel drug therapies aimed at restoring proper cellular function.
