Analytical Data
-
Gene name
NPSR
- Application
-
Alternative Names
NPSR；GPR154；GPRA；PGR14；Neuropeptide S receptor
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q6W5P4
-
Expression Region
1-371aa
-
AA Sequence
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
-
Molecular Weight
42.6 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NPSR (Neuropeptide S receptor) is a G protein-coupled receptor primarily known for its role in the central nervous system, where it interacts with neuropeptide S, influencing various physiological functions such as anxiety, arousal, and stress responses. The study of NPSR is pivotal due to its potential implications in treating neuropsychiatric disorders, including anxiety disorders and depression. As a result, researchers are interested in the structural and functional characterization of NPSR to better understand its signaling mechanisms and therapeutic applications. Recent advances in protein engineering and structural biology techniques, such as X-ray crystallography and cryo-electron microscopy, have facilitated the production of recombinant NPSR. Creating and characterizing NPSR as a recombinant protein allows scientists to probe its binding interactions, conformational dynamics, and downstream signaling pathways in a controlled environment. Additionally, understanding NPSR's interaction with its ligand and other signaling molecules can provide insights into the development of targeted drugs that modulate its activity, potentially leading to new treatment strategies for anxiety and related disorders. Overall, the recombinant study of NPSR is essential for unraveling its biological significance and therapeutic potential, bridging the gap between basic research and clinical application.
