Cat: PA1000-548DB

Recombinant Human CDCA8 Protein,His

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Analytical Data

  • Gene name

    CDCA8

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    CDCA8;PESCRG3;Borealin

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q53HL2

  • Expression Region

    1-280aa

  • AA Sequence

    MAPRKGSSRV AKTNSLRRRK LASFLKDFDR EVEIRIKQIE SDRQNLLKEV DNLYNIEILR LPKALREMNW LDYFALGGNK QALEEAATAD LDITEINKLT AEAIQTPLKS AKTRKVIQVD EMIVEEEEEE ENERKNLQTA RVKRCPPSKK RTQSIQGKGK GKRSSRANTV TPAVGRLEVS MVKPTPGLTP RFDSRVFKTP GLRTPAAGER IYNISGNGSP LADSKEIFLT VPVGGGESLR LLASDLQRHS IAQLDPEALG NIKKLSNRLA QICSSIRTHK

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

CDCA8, also known as Cell Division Cycle Associated Protein 8, plays a crucial role in the regulation of mitosis, particularly during the processes of chromosome alignment and segregation. As a part of the chromosomal passenger complex, CDCA8 is essential for accurate chromosome segregation and is closely linked to the function of the protein Aurora B kinase. Dysregulation of CDCA8 is associated with various types of cancer, making it a potential target for therapeutic intervention. Recent studies have focused on the characterization and expression of recombinant CDCA8 proteins to elucidate its functional mechanisms and interaction partners. This research aims to better understand its role in cell cycle regulation, as well as its contribution to oncogenic processes. By investigating the structural and functional attributes of CDCA8 through recombinant technology, researchers hope to identify novel strategies for cancer treatment and diagnosis, thereby enhancing our understanding of tumor biology and improving patient outcomes.

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