Analytical Data
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基因名
DUSP1
- Application
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别名
DUSP1；CL100；MKP1；PTPN10；Dual specificity Protein phosphatase 1
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种属
Human
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表达系统
E. coli
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标签
N-terminal His Tag
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P28562
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表达区间
1-367aa
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氨基酸序列
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRR RAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGA LCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCS SCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEG HYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICL AYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSP AMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
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分子量
42.7kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
Dual-specificity phosphatase 1 (DUSP1), also known as mitogen-activated protein kinase phosphatase 1 (MKP-1), is a critical enzyme that plays a pivotal role in regulating cellular responses to stress and inflammation. By dephosphorylating both tyrosine and serine/threonine residues, DUSP1 modulates key signaling pathways, including those mediated by mitogen-activated protein kinases (MAPKs) such as ERK, JNK, and p38 MAPK. Dysregulation of DUSP1 has been implicated in various pathological conditions, including cancer, cardiovascular diseases, and autoimmune disorders. The interest in DUSP1 is driven by its potential as a therapeutic target; understanding its structure and function can reveal mechanisms underlying disease progression and treatment resistance. Recent advancements in recombinant protein technology have facilitated the production of DUSP1, allowing for in-depth studies on its biochemical properties, interaction with substrates, and regulatory mechanisms. These studies not only enhance our understanding of DUSP1's role in cellular signaling but also pave the way for the development of pharmacological inhibitors or activators that could modulate its activity for therapeutic benefit. Consequently, research on DUSP1 recombinant protein has become a compelling area of exploration, bridging basic science and clinical applications while offering insights into the fine-tuning of signaling pathways involved in health and disease.
