Analytical Data
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Gene name
TNNT2
- Application
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Alternative Names
TNNT2；Troponin T. cardiac muscle
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P45379-11
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Expression Region
1-285aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MSDIEEVVEE YEEEEQEEAA VEEQEEAAEE DAEAEAETEE TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED EARKKKALSN MMHFGGYIQK TERKSGKRQT EREKKKKILA ERRKVLAIDH LNEDQLREKA KELWQSIYNL EAEKFDLQEK FKQQKYEINV LRNRINDNQK VSKTRGKAKV TGRWK
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Molecular Weight
36 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TNNT2, or cardiac troponin T, is a crucial protein in the cardiac muscle contraction process, playing a vital role in the regulation of calcium-dependent muscle contraction. Mutations in the TNNT2 gene have been strongly associated with familial hypertrophic cardiomyopathy (FHC), a common genetic heart disease that can lead to sudden cardiac death and heart failure. Given its importance in cardiac physiology and pathology, TNNT2 has become a focal point for research aimed at understanding the mechanisms underlying cardiac diseases and developing targeted therapies. Recombination technology allows for the production of recombinant TNNT2 protein, which facilitates detailed studies on its structure-function relationship, the effects of disease-related mutations, and the development of potential therapeutic interventions. Investigating the recombinant TNNT2 protein not only enhances our understanding of its role in sarcomere function but also aids in the identification of biomarkers for cardiac diseases, paving the way for novel diagnostic and therapeutic strategies.
