Analytical Data
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基因名
GRO-alpha/CXCL1
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简介
CXCL1 (Chemokine (C-X-C motif) ligand 1), also known as GRO alpha, NAP-3 or MGSA, belongs to the sub-family of CXC chemokine. CXCL1 is involved in the development of many inflammatory diseases, including the induction of angiogenesis and recruitment of neutrophils. CXCL1 is produced by many cell types, and activates CXCR2 and, at high levels, CXCR1[1]. GRO-alpha/CXCL1 Protein, Mouse (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 77 amino acids (A20-N96).
- Application
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别名
Growth-regulated alpha protein; C-X-C motif chemokine 1; HSF; KC-T; CXCL1; GROa
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种属
Mouse
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P12850
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表达区间
R20-K96
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蛋白长度
Full Length of Mature Protein
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分子量
10-13 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRO-alpha, also known as CXCL1, is a CXC chemokine involved in the inflammatory response and plays a crucial role in the recruitment of neutrophils to sites of injury or infection. Research on GRO-alpha/CXCL1 has gained significant attention due to its involvement in various physiological and pathological processes, including cancer progression, wound healing, and immune responses. Elevated levels of GRO-alpha have been associated with tumor growth, angiogenesis, and metastasis, making it a potential biomarker for various cancers. Additionally, GRO-alpha is implicated in chronic inflammatory diseases, such as rheumatoid arthritis and chronic obstructive pulmonary disease (COPD), highlighting its relevance in understanding inflammation-induced tissue damage. The study of recombinant GRO-alpha protein has advanced our knowledge of its structure-function relationships and allowed for the exploration of its therapeutic applications, such as targeted cancer therapies and anti-inflammatory treatments. By utilizing recombinant technology, researchers can produce GRO-alpha in a controlled manner, facilitating the investigation of its biological activities and the development of inhibitors that modulate its function in pathological conditions. Overall, the comprehensive understanding of GRO-alpha/CXCL1's role in both health and disease underscores the importance of ongoing research in this area, paving the way for novel therapeutic strategies.
