Analytical Data
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基因名
ATP1B1
- Application
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别名
ATP1B1；ATP1B；Sodium/potassium-transporting ATPase subunit beta-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P05026
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表达区间
63-303aa
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氨基酸序列
ADPEFKPTYQ DRVAPPGLTQ IPQIQKTEIS FRPNDPKSYE AYVLNIVRFL EKYKDSAQRD DMIFEDCGDV PSEPKERGDF NHERGERKVC RFKLEWLGNC SGLNDETYGY KEGKPCIIIK LNRVLGFKPK PPKNESLETY PVMKYNPNVL PVQCTGKRDE DKDKVGNVEY FGLGNSPGFP LQYYPYYGKL LQPKYLQPLL AVQFTNLTMD TEIRIECKAY GENIGYSEKD RFQGRFDVKI EVKSHHHHHH
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分子量
29 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATP1B1, also known as the ATPase Na+/K+ transporting subunit beta 1, is a critical protein that plays a vital role in maintaining cellular ion balance by functioning as a component of the Na+/K+ ATPase pump. This enzyme regulates the concentration of sodium and potassium ions across the plasma membrane, which is essential for various cellular processes, including nutrient uptake, cell volume regulation, and electrical excitability in neurons and muscle cells. Mutations in the ATP1B1 gene have been associated with a range of pathologies, such as hypertension and neurological disorders, highlighting its importance in human health. Researchers have increasingly focused on characterizing recombinant forms of ATP1B1 to better understand its functional mechanisms and interactions with other cellular components, as well as its role in disease processes. The generation of recombinant ATP1B1 proteins allows for detailed studies of its biophysical properties, enzymatic activity, and response to pharmacological agents, which can lead to the identification of novel therapeutic targets. Further investigation into the mechanistic insights provided by recombinant ATP1B1 could pave the way for new treatment strategies for conditions linked to ion transport dysregulation, underscoring the relevance of this protein in both basic and applied biomedical research.
