Analytical Data
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基因名
ASF1B
- Application
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别名
ASF1B；Histone chaperone ASF1B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NVP2
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表达区间
1-202aa
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氨基酸序列
MAKVSVLNVA VLENPSPFHS PFRFEISFEC SEALADDLEW KIIYVGSAES EEFDQILDSV LVGPVPAGRH MFVFQADAPN PSLIPETDAV GVTVVLITCT YHGQEFIRVG YYVNNEYLNP ELRENPPMKP DFSQLQRNIL ASNPRVTRFH INWDNNMDRL EAIETQDPSL GCGLPLNCTP IKGLGLPGCI PGLLPENSMD
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分子量
23 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ASF1B (Anti-Silencing Function 1B) is a histone chaperone that plays a crucial role in various cellular processes, including DNA replication, repair, and transcription regulation. It operates by facilitating the assembly and disassembly of histone proteins, thereby influencing chromatin structure and function. Recent studies have shown that ASF1B is unique in its capacity to interact with specific histone variants, highlighting its potential role in epigenetic regulation. The dysregulation of ASF1B has been implicated in several cancers, making it a target of interest for therapeutic strategies. Furthermore, research has indicated its involvement in the cellular stress response, suggesting that ASF1B could be pivotal in maintaining genomic stability under adverse conditions. Investigating the molecular mechanisms of ASF1B and its interactome is fundamental to understanding its contributions to cell biology and disease states. Given its significance in both normal and pathological conditions, ASF1B continues to attract attention in the fields of molecular biology and cancer research, with ongoing studies aiming to elucidate its functions and potential as a biomarker or therapeutic target.
