Analytical Data
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基因名
ARC
- Application
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别名
ARC；KIAA0278；Activity-regulated cytoskeleton-associated Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7LC44
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表达区间
1-396aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMELDHRTSGGLHAYPGPRGGQVAKPNVILQ IGKCRAEMLEHVRRTHRHLLAEVSKQVERELKGLHRSVGKLESNLDGYVP TSDSQRWKKSIKACLCRCQETIANLERWVKREMHVWREVFYRLERWADRL ESTGGKYPVGSESARHTVSVGVGGPESYCHEADGYDYTVSPYAITPPPAA GELPGQEPAEAQQYQPWVPGEDGQPSPGVDTQIFEDPREFLSHLEEYLRQ VGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLS REAIQRELDLPQKQGEPLDQFLWRKRDLYQTLYVDADEEEIIQYVVGTLQ PKLKRFLRHPLPKTLEQLIQRGMEVQDDLEQAAEPAGPHLPVEDEAETLT PAPNSESVASDRTQPE
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分子量
47 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARC (Activity-Regulated Cytoskeleton-associated Protein) is a neuronal activity-regulated protein that plays a crucial role in synaptic plasticity and memory formation. Its significance has been highlighted in various studies linking it to the mechanisms underlying learning and memory at the synaptic level. Research has shown that ARC is upregulated in response to synaptic stimulation and is involved in the internalization of AMPA receptors, which are essential for synaptic transmission. Disruptions in ARC function have been associated with neurodevelopmental and neurodegenerative disorders, making it a target of increasing interest in both basic neuroscience and therapeutic research. The ability of ARC to influence synaptic dynamics provides insights into the molecular mechanisms of cognitive function and offers potential avenues for the development of interventions in conditions where cognitive function is impaired. As studies progress, understanding the precise molecular interactions and signaling pathways involving ARC is expected to enhance our comprehension of synaptic behavior and its implications for learning and memory processes. These insights may pave the way for novel therapeutic strategies aimed at manipulating ARC activity to ameliorate cognitive deficits associated with various neurological conditions.
