Analytical Data
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Gene name
ARC
- Application
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Alternative Names
ARC；KIAA0278；Activity-regulated cytoskeleton-associated Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7LC44
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Expression Region
1-396aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMELDHRTSGGLHAYPGPRGGQVAKPNVILQ IGKCRAEMLEHVRRTHRHLLAEVSKQVERELKGLHRSVGKLESNLDGYVP TSDSQRWKKSIKACLCRCQETIANLERWVKREMHVWREVFYRLERWADRL ESTGGKYPVGSESARHTVSVGVGGPESYCHEADGYDYTVSPYAITPPPAA GELPGQEPAEAQQYQPWVPGEDGQPSPGVDTQIFEDPREFLSHLEEYLRQ VGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLS REAIQRELDLPQKQGEPLDQFLWRKRDLYQTLYVDADEEEIIQYVVGTLQ PKLKRFLRHPLPKTLEQLIQRGMEVQDDLEQAAEPAGPHLPVEDEAETLT PAPNSESVASDRTQPE
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Molecular Weight
47 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARC (Activity-Regulated Cytoskeleton-associated Protein) is a neuronal activity-regulated protein that plays a crucial role in synaptic plasticity and memory formation. Its significance has been highlighted in various studies linking it to the mechanisms underlying learning and memory at the synaptic level. Research has shown that ARC is upregulated in response to synaptic stimulation and is involved in the internalization of AMPA receptors, which are essential for synaptic transmission. Disruptions in ARC function have been associated with neurodevelopmental and neurodegenerative disorders, making it a target of increasing interest in both basic neuroscience and therapeutic research. The ability of ARC to influence synaptic dynamics provides insights into the molecular mechanisms of cognitive function and offers potential avenues for the development of interventions in conditions where cognitive function is impaired. As studies progress, understanding the precise molecular interactions and signaling pathways involving ARC is expected to enhance our comprehension of synaptic behavior and its implications for learning and memory processes. These insights may pave the way for novel therapeutic strategies aimed at manipulating ARC activity to ameliorate cognitive deficits associated with various neurological conditions.
