Analytical Data
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Gene name
HESRG
- Application
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Alternative Names
ESRG; HESRG; Embryonic stem cell-related gene protein; hES cell-related gene protein
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q1W209
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Expression Region
1-222aa
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Molecular Weight
28.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HESRG (Hypoxia-Inducible Factor Regulated Gene) protein has garnered interest due to its involvement in various biological processes, particularly in response to hypoxic conditions. Hypoxia, a state of reduced oxygen availability, triggers adaptive cellular mechanisms for survival and proliferation, which are crucial in pathophysiological contexts such as cancer, ischemia, and tissue regeneration. Studies have indicated that HESRG plays a pivotal role in regulating gene expression linked to cellular responses under low oxygen levels, potentially influencing tumor growth and metastasis. The recombinant expression of HESRG presents a method for investigating its functional properties, including its interaction with other proteins and pathways associated with hypoxia. Researchers aim to elucidate the mechanism of HESRG in cellular signaling and its potential therapeutic implications. By producing HESRG as a recombinant protein, scientists can perform a variety of assays, including binding studies and functional assays, which could provide insights into its role in cellular adaptation to hypoxic stress. Given the protein's relevance in significant diseases, including cancer, understanding HESRG’s mechanism could pave the way for innovative therapeutic strategies targeting hypoxia-related pathways. Overall, HESRG's study as a recombinant protein represents a vital step toward unraveling the complexities of cellular adaptation to hypoxia and its associated health implications.
