Analytical Data
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Gene name
ANGPTL6
- Application
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Alternative Names
ANGPTL6；AGF；ARP5；Angiopoietin-related Protein 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NI99
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Expression Region
21-470aa
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AA Sequence
RAGAPRCTYTFVLPPQKFTGAVCWSGPASTRATPEAANASELAALRMRVGRHEELLRELQRLAAADGAVAGEVRALRKESRGLSARLGQLRAQLQHEAGPGAGPGADLGAEPAAALALLGERVLNASAEAQRAAARFHQLDVKFRELAQLVTQQSSLIARLERLCPGGAGGQQQVLPPPPLVPVVPVRLVGSTSDTSRMLDPAPEPQRDQTQRQQEPMASPMPAGHPAVPTKPVGPWQDCAEARQAGHEQSGVYELRVGRHVVSVWCEQQLEGGGWTVIQRRQDGSVNFFTTWQHYKAGFGRPDGEYWLGLEPVYQLTSRGDHELLVLLEDWGGRGARAHYDGFSLEPESDHYRLRLGQYHGDAGDSLSWHNDKPFSTVDRDRDSYSGNCALYQRGGWWYHACAHSNLNGVWHHGGHYRSRYQDGVYWAEFRGGAYSLRKAAMLIRPLKL
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Molecular Weight
56.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ANGPTL6, also known as angiopoietin-like protein 6, is a member of the angiopoietin-like family, which plays crucial roles in various physiological processes, particularly in regulating lipid metabolism, glucose homeostasis, and inflammation. Initially identified as an endothelial cell growth factor, ANGPTL6 has garnered attention for its potential involvement in metabolic diseases, including obesity and type 2 diabetes. Research indicates that ANGPTL6 acts as a regulator of triglyceride metabolism by inhibiting lipoprotein lipase, thus influencing plasma lipid levels. Its expression is primarily found in the liver, adipose tissue, and skeletal muscle, linking it to energy homeostasis. Furthermore, recent studies have suggested that ANGPTL6 may possess angiogenic properties and could be involved in tissue repair processes. Given its multifaceted roles, the development of recombinant ANGPTL6 protein has become a focus for researchers aiming to elucidate its underlying mechanisms and therapeutic potential. Studies involving the recombinant form of ANGPTL6 may reveal insights into its signaling pathways and interactions, paving the way for novel interventions in metabolic disorders and cardiovascular diseases. Understanding the functional aspects of ANGPTL6 could inform the development of targeted therapies to modulate lipid metabolism and improve metabolic health, highlighting its significance in both basic research and clinical applications.
