Analytical Data
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Gene name
ANGPT4
- Application
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Alternative Names
ANGPT4；ANG3；ANG4；Angiopoietin-4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y264
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Expression Region
25-503aa
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AA Sequence
TRQEAD RGCETLVVQH GHCSYTFLLP KSEPCPPGPE VSRDSNTLQR ESLANPLHLG KLPTQQVKQL EQALQNNTQW LKKLERAIKT ILRSKLEQVQ QQMAQNQTAP MLELGTSLLN QTTAQIRKLT DMEAQLLNQT SRMDAQMPET FLSTNKLENQ LLLQRQKLQQ LQGQNSALEK RLQALETKQQ EELASILSKK AKLLNTLSRQ SAALTNIERG LRGVRHNSSL LQDQQHSLRQ LLVLLRHLVQ ERANASAPAF IMAGEQVFQD CAEIQRSGAS ASGVYTIQVS NATKPRKVFC DLQSSGGRWT LIQRRENGTV NFQRNWKDYK QGFGDPAGEH WLGNEVVHQL TRRAAYSLRV ELQDWEGHEA YAQYEHFHLG SENQLYRLSV VGYSGSAGRQ SSLVLQNTSF STLDSDNDHC LCKCAQVMSG GWWFDACGLS NLNGVYYHAP DNKYKMDGIR WHYFKGPSYS LRASRMMIRP LDI
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ANGPT4 (Angiopoietin 4) is a member of the angiopoietin family of proteins that plays a crucial role in vascular development, inflammation, and metabolism. Initially identified as an angiogenic factor, ANGPT4 has garnered attention for its multifaceted contributions beyond just influencing blood vessel formation. Research indicates that ANGPT4 is involved in processes such as modulating endothelial cell function, supporting the blood-brain barrier, and participating in metabolic regulation, particularly in the context of obesity and diabetes. Dysregulation of ANGPT4 expression has been linked to various diseases, including cancer and cardiovascular disorders, positioning it as a potential biomarker and therapeutic target. The recombinant expression and characterization of ANGPT4 protein are essential for understanding its biological functions and implications in health and disease. Advances in recombinant protein technology have facilitated the production of ANGPT4, enabling researchers to explore its mechanisms of action and therapeutic applications more effectively. Studying ANGPT4 in a recombinant form allows for detailed analyses of its interactions with receptors, identification of signaling pathways, and evaluation of its potential in drug development, particularly in conditions where angiogenesis and metabolism are disrupted. As research into ANGPT4 continues to evolve, its role as a key player in various physiological and pathological processes offers promising avenues for clinical interventions and understanding complex disease mechanisms.
