Analytical Data
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Gene name
AKAP7
- Application
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Alternative Names
AKAP7；AKAP18；A-kinase anchor Protein 7 isoform gamma
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43687
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Expression Region
1-81aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMGQLCC FPFSRDEGKI SEKNGGEPDD AELVRLSKRL VENAVLKAVQ QYLEETQNKN KPGEGSSVKTEAADQNGNDN ENNRK
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Molecular Weight
12 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AKAP7 (A-kinase anchoring protein 7) is a member of the AKAP family, which plays a crucial role in the spatial and temporal regulation of protein kinase A (PKA) signaling pathways. These proteins are essential for organizing signaling complexes within cells, thereby ensuring that PKA is activated in specific subcellular locations, which is vital for the modulation of various physiological processes, including cell proliferation, differentiation, and apoptosis. Studies have shown that AKAP7 is implicated in the regulation of heart function, neuronal signaling, and synaptic plasticity. Its unique structure, which allows for the binding of PKA and other signaling molecules, makes it a focal point of research in understanding complex signaling networks. Additionally, abnormalities in AKAP7 expression or function have been linked to several diseases, including cardiac disorders and neurodegenerative conditions. The recombinant expression of AKAP7 provides a valuable tool for investigating its role in these pathways and exploring its potential as a therapeutic target. By elucidating the molecular mechanisms underlying AKAP7's functions, researchers aim to uncover novel insights into the intricate signaling cascades that govern cellular responses, paving the way for innovative treatments for related diseases.
