Analytical Data
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Gene name
hrp1
- Application
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Alternative Names
hrp1; Rv2626cHypoxic response protein 1; HRP1
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Species
Mycobacterium tuberculosis
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Source
E. coli
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Tag
N- His-SUMO & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P9WJA3
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Expression Region
1-143aa
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Molecular Weight
35.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HRP1, or Human RNA Polymerase I, is a crucial enzyme involved in the transcription of ribosomal RNA (rRNA), a fundamental process for ribosome biogenesis and protein synthesis in eukaryotic cells. The study of HRP1 is vital due to its significant role in cellular growth and proliferation, making it a potential target for cancer therapies. Abnormalities in rRNA synthesis and ribosome function can contribute to various diseases, including cancer, highlighting the importance of understanding HRP1's structure and function. Researchers have been focusing on the recombination of HRP1 to investigate its enzymatic mechanisms, interactions with regulatory factors, and impact on ribosome assembly. By studying HRP1 recombinant proteins, scientists aim to elucidate its role in the transcriptional regulation of rRNA genes and how its dysregulation may lead to pathological conditions. Overall, the research into HRP1 and its recombinant forms not only enhances our understanding of fundamental cellular processes but also opens avenues for innovative therapeutic strategies targeting ribosome biogenesis in disease contexts.
