Analytical Data
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基因名
hrp1
- Application
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别名
hrp1; Rv2626cHypoxic response protein 1; HRP1
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种属
Mycobacterium tuberculosis
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表达系统
E. coli
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标签
N- His-SUMO & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P9WJA3
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表达区间
1-143aa
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分子量
35.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HRP1, or Human RNA Polymerase I, is a crucial enzyme involved in the transcription of ribosomal RNA (rRNA), a fundamental process for ribosome biogenesis and protein synthesis in eukaryotic cells. The study of HRP1 is vital due to its significant role in cellular growth and proliferation, making it a potential target for cancer therapies. Abnormalities in rRNA synthesis and ribosome function can contribute to various diseases, including cancer, highlighting the importance of understanding HRP1's structure and function. Researchers have been focusing on the recombination of HRP1 to investigate its enzymatic mechanisms, interactions with regulatory factors, and impact on ribosome assembly. By studying HRP1 recombinant proteins, scientists aim to elucidate its role in the transcriptional regulation of rRNA genes and how its dysregulation may lead to pathological conditions. Overall, the research into HRP1 and its recombinant forms not only enhances our understanding of fundamental cellular processes but also opens avenues for innovative therapeutic strategies targeting ribosome biogenesis in disease contexts.
