Analytical Data
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基因名
IGF2BP3
- Application
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别名
IGF2BP3；HUR；ELAV-like Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00425
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表达区间
1-579aa
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氨基酸序列
MNKLYIGNLSENAAPSDLESIFKDAKIPVSGPFLVKTGYAFVDCPDESWALKAIEALSGKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAAQQNPLQQPRGRRGLGQRGSSRQGSPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSAMTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK
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分子量
69.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IGF2BP3 (Insulin-like Growth Factor 2 mRNA Binding Protein 3) is an RNA-binding protein that plays a crucial role in regulating mRNA stability and translation, influencing cellular processes such as growth and differentiation. This protein is often overexpressed in various cancers, including colorectal, breast, and liver cancers, suggesting its potential as a prognostic marker and therapeutic target. The dysregulation of IGF2BP3 is believed to contribute to tumor progression by stabilizing oncogenic mRNAs and promoting cell proliferation while inhibiting apoptosis. Recent research has focused on elucidating the molecular mechanisms underlying IGF2BP3's role in cancer, including its interactions with specific mRNAs and other regulatory proteins. Furthermore, the production of recombinant IGF2BP3 has emerged as a promising approach for studying its functional properties and for developing new therapeutic strategies targeting its role in cancer. Through structural and functional analyses, researchers aim to understand how IGF2BP3 contributes to the malignant phenotype, laying the groundwork for potential interventions that could disrupt its functions in cancer progression. This understanding is essential for the development of novel biomarkers and therapeutic agents that can improve patient outcomes in cancers associated with IGF2BP3 overexpression.
