Analytical Data
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Gene name
IGF2BP3
- Application
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Alternative Names
IGF2BP3；HUR；ELAV-like Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00425
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Expression Region
1-579aa
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AA Sequence
MNKLYIGNLSENAAPSDLESIFKDAKIPVSGPFLVKTGYAFVDCPDESWALKAIEALSGKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAAQQNPLQQPRGRRGLGQRGSSRQGSPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSAMTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK
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Molecular Weight
69.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IGF2BP3 (Insulin-like Growth Factor 2 mRNA Binding Protein 3) is an RNA-binding protein that plays a crucial role in regulating mRNA stability and translation, influencing cellular processes such as growth and differentiation. This protein is often overexpressed in various cancers, including colorectal, breast, and liver cancers, suggesting its potential as a prognostic marker and therapeutic target. The dysregulation of IGF2BP3 is believed to contribute to tumor progression by stabilizing oncogenic mRNAs and promoting cell proliferation while inhibiting apoptosis. Recent research has focused on elucidating the molecular mechanisms underlying IGF2BP3's role in cancer, including its interactions with specific mRNAs and other regulatory proteins. Furthermore, the production of recombinant IGF2BP3 has emerged as a promising approach for studying its functional properties and for developing new therapeutic strategies targeting its role in cancer. Through structural and functional analyses, researchers aim to understand how IGF2BP3 contributes to the malignant phenotype, laying the groundwork for potential interventions that could disrupt its functions in cancer progression. This understanding is essential for the development of novel biomarkers and therapeutic agents that can improve patient outcomes in cancers associated with IGF2BP3 overexpression.
