Analytical Data
-
Gene name
OPRM1
- Application
-
Alternative Names
Mu-type opioid receptor(M-OR-1)(MOR-1)(Mu opiate receptor)(Mu opioid receptor)(MOP)(hMOP)
-
Species
Human
-
Source
E. coli
-
Tag
N- His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P35372
-
Expression Region
1-400aa
-
Molecular Weight
47.6 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
OPRM1, or the μ-opioid receptor, is a key protein in the body's pain modulation system and plays a crucial role in mediating the effects of opioids, which are widely used for pain relief but can lead to addiction and other adverse effects. The receptor is encoded by the OPRM1 gene, which exhibits genetic polymorphisms that can influence individual responses to opioid therapy and susceptibility to addiction. Recent research has focused on the functional characterization of OPRM1, including its expression in various tissues, signaling pathways, and interactions with different ligands, including endogenous peptides and synthetic drugs. The development of recombinant OPRM1 proteins has facilitated detailed studies on receptor pharmacology, structure-function relationships, and the identification of novel compounds that can modulate receptor activity for therapeutic applications. Furthermore, understanding the molecular mechanisms underlying OPRM1 function is vital for addressing issues of opioid efficacy and safety, paving the way for more personalized medicine approaches in pain management and addiction treatment. As the opioid crisis continues to pose significant public health challenges, ongoing research into OPRM1 and its signaling pathways remains essential for developing safer and more effective analgesics that minimize the risk of dependence.
