Analytical Data
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基因名
Gnrh1
- Application
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别名
Progonadoliberin-1(Progonadoliberin I) [Cleaved into: Gonadoliberin-1(Gonadoliberin I)(Gonadotropin-releasing hormone I)(GnRH-I)(Luliberin I)(Luteinizing hormone-releasing hormone I)(LH-RH I); Prolactin release-inhibiting factor 1(Prolactin release-inhibiting factor I)]
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种属
Rat
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P07490
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表达区间
24-92aa
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分子量
12.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Gonadotropin-releasing hormone 1 (GnRH1) is a pivotal neuropeptide that plays a crucial role in the regulation of the reproductive axis in vertebrates. It orchestrates the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland, which in turn control gonadal function and influence sexual maturation and fertility. Dysregulation of GnRH1 signaling is implicated in various reproductive disorders, making it a target for therapeutic interventions. Research on recombinant GnRH1 proteins has gained momentum due to their potential applications in reproductive health, such as in treatments for hypothalamic amenorrhea, infertility, and hormone-related cancers. The production of recombinant GnRH1 allows for detailed studies on its structure-function relationships and mechanisms of action, paving the way for innovative approaches in endocrinology and reproductive medicine. Advances in biotechnology have facilitated the expression and purification of GnRH1, enabling the exploration of its biological properties and the development of GnRH1 analogs that can enhance or inhibit its activity. Understanding the nuances of GnRH1 at the molecular level holds promise for creating more effective therapies for managing conditions linked to reproductive health, thereby enhancing our knowledge of the neuroendocrine regulation of reproduction.
