Analytical Data
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Gene name
PATL1
- Application
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Alternative Names
PAT1-like protein 1;Protein PAT1 homolog b;Pat1b;hPat1b
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86TB9
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Expression Region
1–770aa
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Molecular Weight
89.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PATL1 (Processing Body Assembly Factor 1) is a crucial protein involved in the regulation of mRNA metabolism and localization, particularly in RNA processing bodies (PBs). Research on PATL1 has gained momentum due to its significant role in cellular responses to stress and its implications in various biological processes, including cell division, differentiation, and response to environmental changes. The protein is known to interact with multiple RNA-binding proteins and is essential for maintaining mRNA stability, thereby influencing gene expression. Abnormalities in PATL1 function have been associated with several diseases, including cancer, where dysregulation of mRNA metabolism can lead to uncontrolled cell growth. Consequently, understanding the structure and function of PATL1, as well as the mechanisms by which it regulates RNA dynamics, could provide insights into new therapeutic strategies. Recent studies employing recombinant techniques to express and purify PATL1 have highlighted its potential as a target for drug development, offering a pathway to leverage its role in mRNA processing and gene regulation for therapeutic purposes. Furthermore, elucidating the interaction networks involving PATL1 could uncover novel regulators of cellular homeostasis and disease progression. Therefore, the investigation of PATL1 recombinant proteins represents a promising area of research, with the potential to advance our understanding of RNA biology and contribute to the development of innovative treatments for related pathologies.
