Analytical Data
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Gene name
gata1-a
- Application
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Alternative Names
Transcription factor xGATA-1A
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Species
Xenopus laevis
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Source
E. coli
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Tag
N- His-SUMO & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P23767
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Expression Region
1-359aa
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Molecular Weight
59 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GATA1-A is a vital transcription factor that plays a critical role in hematopoiesis and the development of various cell lineages, particularly in erythrocytes and megakaryocytes. The study of GATA1-A recombinant protein has garnered significant attention due to its involvement in essential biological processes and its implications in various health conditions, including anemia and blood disorders. Abnormalities in GATA1 function can lead to severe consequences, such as congenital blood malformations and hematopoietic malignancies. Consequently, understanding the structure and function of GATA1-A through recombinant protein studies is crucial for elucidating its regulatory mechanisms and target genes. Researchers aim to produce GATA1-A in a recombinant form to facilitate functional assays and structural analyses, providing insights into its molecular interactions and post-translational modifications. By investigating the therapeutic potential of modulating GATA1-A activity, scientists hope to develop innovative strategies for treating diseases linked to GATA1 dysregulation. Overall, the exploration of GATA1-A recombinant protein is pivotal in advancing our understanding of hematopoietic biology and offers prospects for targeted interventions in related disorders.
