Analytical Data
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Gene name
CHMP7
- Application
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Alternative Names
Chromatin-modifying protein 7
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WUX9
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Expression Region
1-453aa
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Molecular Weight
56.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CHMP7 (charged multivesicular body protein 7) is a member of the ESCRT (Endosomal Sorting Complex Required for Transport) machinery, which plays a crucial role in various cellular processes, including endosomal trafficking, cytokinesis, and the maintenance of cellular homeostasis. Recent studies have highlighted CHMP7's involvement in the selective degradation of membrane proteins and its significant role in the biogenesis of Exosomes, which are small extracellular vesicles involved in intercellular communication and the transfer of proteins and genetic material. The dysfunction of CHMP7 has been linked to several diseases, including neurodegenerative disorders and cancer, making it a key target for therapeutic interventions. The production and characterization of recombinant CHMP7 protein enable researchers to gain insights into its structural and functional properties, and to explore its interactions with other ESCRT components. Furthermore, understanding the dynamics of CHMP7 at a molecular level can shed light on the mechanisms underlying endosomal sorting and the potential for modulating its activity in pathological conditions. As research progresses, recombinant CHMP7 proteins may also serve as valuable tools in drug delivery systems and nanotechnology applications, further expanding their relevance in biomedical research.
