Analytical Data
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基因名
CRACR2B
- Application
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别名
Calcium release-activated calcium channel regulator 2B;CRAC channel regulator 2B;Calcium release-activated channel regulator 2B
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N4Y2
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表达区间
1–399aa
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分子量
47.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRACR2B, or Calcium-Dependent Receptor Activator of NF-kB (CRACR2B), is a protein that plays a pivotal role in the regulation of calcium signaling and the immune response. This protein is mainly expressed in hematopoietic cells and has been implicated in various cellular processes, including T-cell activation and cytokine production. The study of CRACR2B has gained attention due to its involvement in the modulation of NF-kB signaling pathways, which are crucial for inflammatory responses and immune system regulation. Dysregulation of these pathways has been linked to numerous autoimmune diseases and cancers. Recent research has focused on the molecular mechanisms by which CRACR2B influences these pathways and its potential as a therapeutic target. Understanding CRACR2B’s interactions with various proteins and signaling molecules could provide insights into the development of new treatments for immune-related disorders. Additionally, investigating the structural characteristics of recombinant CRACR2B protein can elucidate its functional roles and offer opportunities for bioengineering applications. As such, CRACR2B stands at the intersection of immunology, cell biology, and protein engineering, representing a significant area of study with potential implications for health and disease management.
