Analytical Data
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基因名
ARHGEF12
- Application
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别名
Leukemia-associated RhoGEF
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZN5
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表达区间
367-558aa
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分子量
28.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARHGEF12, also known as Trio, is a member of the Rho guanine nucleotide exchange factor (GEF) family, which plays a critical role in modulating Rho GTPase signaling pathways. These pathways are essential for various cellular processes, including cell migration, adhesion, and cytoskeletal dynamics, which are pivotal during developmental processes and in maintaining tissue homeostasis. Dysregulation of ARHGEF12 has been implicated in several pathological conditions, including cancer and cardiovascular diseases, making it a significant target for therapeutic interventions. Research into ARHGEF12 often focuses on its structure-function relationships, the mechanisms through which it activates Rho GTPases, and its interactions with other signaling molecules. Recombinant ARHGEF12 protein is utilized in these studies to elucidate its role in cellular signaling and to explore its potential as a biomarker or therapeutic target. The production of this protein in a laboratory setting allows for detailed in vitro assays, providing insights into how ARHGEF12 contributes to disease progression and identifying possible avenues for drug development. Understanding the functional characteristics of ARHGEF12 not only enhances our knowledge of cellular signaling networks but also holds promise for innovative treatment strategies aimed at diseases associated with its dysfunction.
