Analytical Data
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Gene name
FBXO44
- Application
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Alternative Names
F-box protein FBX30 F-box/G-domain protein 3
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Species
Human
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H4M3
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Expression Region
1-255aa
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Molecular Weight
37.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXO44, a member of the F-box protein family, plays a crucial role in the ubiquitin-proteasome pathway, which regulates protein degradation and turnover within the cell. It serves as a substrate recognition component of E3 ubiquitin ligases, facilitating the transfer of ubiquitin moieties to target proteins, thus marking them for proteasomal degradation. Recent studies suggest that FBXO44 is involved in various cellular processes, including cell cycle regulation, apoptosis, and signal transduction, indicating its potential significance in maintaining cellular homeostasis and responding to stress. Dysregulation of FBXO44 has been implicated in several pathological conditions, including cancer, neurodegenerative diseases, and metabolic disorders, highlighting its importance in human health. Understanding the structure and function of FBXO44, particularly through the development and characterization of recombinant FBXO44 protein, can provide insights into its biological roles and interactions. By using recombinant techniques, researchers can produce FBXO44 in a controlled environment, allowing for in-depth biochemical and biophysical studies, including elucidation of its substrate specificity and binding dynamics. Such research could pave the way for novel therapeutic interventions, targeting the pathways influenced by FBXO44 to manipulate disease outcomes effectively.
