Analytical Data
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基因名
FBXO44
- Application
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别名
F-box protein FBX30 F-box/G-domain protein 3
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H4M3
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表达区间
1-255aa
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分子量
37.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXO44, a member of the F-box protein family, plays a crucial role in the ubiquitin-proteasome pathway, which regulates protein degradation and turnover within the cell. It serves as a substrate recognition component of E3 ubiquitin ligases, facilitating the transfer of ubiquitin moieties to target proteins, thus marking them for proteasomal degradation. Recent studies suggest that FBXO44 is involved in various cellular processes, including cell cycle regulation, apoptosis, and signal transduction, indicating its potential significance in maintaining cellular homeostasis and responding to stress. Dysregulation of FBXO44 has been implicated in several pathological conditions, including cancer, neurodegenerative diseases, and metabolic disorders, highlighting its importance in human health. Understanding the structure and function of FBXO44, particularly through the development and characterization of recombinant FBXO44 protein, can provide insights into its biological roles and interactions. By using recombinant techniques, researchers can produce FBXO44 in a controlled environment, allowing for in-depth biochemical and biophysical studies, including elucidation of its substrate specificity and binding dynamics. Such research could pave the way for novel therapeutic interventions, targeting the pathways influenced by FBXO44 to manipulate disease outcomes effectively.
