Analytical Data
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Gene name
TOMM40
- Application
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Alternative Names
Protein Haymaker Translocase of outer membrane 40KDA subunit homolog p38.5
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O96008
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Expression Region
1-361aa
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Molecular Weight
64.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TOMM40, or Translocase of Outer Mitochondrial Membrane 40, is a gene that plays a critical role in the import of proteins into mitochondria, which are essential for cellular energy production and overall cellular function. Research has increasingly highlighted the association between TOMM40 and neurodegenerative diseases, particularly Alzheimer's disease. Variants in the TOMM40 gene have been linked to variations in age-related cognitive decline and the risk of developing Alzheimer's, suggesting that it may influence mitochondrial function and neuronal health. The gene's poly-T polymorphism, a repeated sequence in its structure, has garnered attention for its potential role in modulating cognitive resilience and susceptibility to Alzheimer's. The study of TOMM40 and its recombinant proteins aims to elucidate the mechanisms by which mitochondrial dysfunction contributes to neurodegeneration. Understanding these pathways holds promise for developing targeted therapies and interventions. As such, TOMM40 stands at the intersection of genetics, neurobiology, and mitochondrial research, making it a focal point of interest for scientists aiming to uncover the underlying causes of neurodegenerative diseases and to identify novel therapeutic strategies.
