Analytical Data
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Gene name
TMEM14B
- Application
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Alternative Names
FLJ60468; MGC1223; OTTHUMP00000214289; OTTHUMP00000214290; OTTHUMP00000214297; OTTHUMP00000214298; OTTHUMP00000214299; RP3-417M14.1; TM14B_HUMAN; TMEM14B; Transmembrane protein 14B
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NUH8
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Expression Region
1-114aa
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Molecular Weight
39.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMEM14B, a member of the transmembrane protein family, has garnered attention due to its potential role in various biological processes and disease states. This protein is primarily localized in the endoplasmic reticulum, where it may play a critical role in maintaining cellular homeostasis and participating in lipid metabolism. Studies have suggested that TMEM14B is involved in regulating cellular stress responses, which links it to neurodegenerative disorders and other pathologies. Its expression levels have been associated with certain cancers, indicating a possible role in tumorigenesis and progression. Consequently, the recombinant expression and purification of TMEM14B are essential for elucidating its structure-function relationships and understanding its biological significance. The generation of TMEM14B recombinant proteins allows researchers to investigate its interactions with other cellular components and assess its functional roles in a controlled environment. This research not only aids in the elucidation of TMEM14B's mechanisms but also paves the way for therapeutic applications targeting diseases related to its dysfunction. Overall, the study of TMEM14B promises to provide insights into the crucial roles of transmembrane proteins in human health and disease.
