Analytical Data
-
Gene name
SRP19
- Application
-
Alternative Names
Signal recognition particle 19 kDa protein; signal recognition particle 19kDa; SRP19; SRP19_HUMAN
-
Species
Human
-
Source
E. coli
-
Tag
N- His-SUMO
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P09132
-
Expression Region
2-144aa
-
Molecular Weight
32 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SRP19, a crucial component of the signal recognition particle (SRP) pathway, plays a significant role in the targeting and translocation of nascent polypeptides to the endoplasmic reticulum (ER) in eukaryotic cells. The SRP complex, comprising RNA and proteins, ensures the proper localization of secretory and membrane proteins, which is vital for cellular function and homeostasis. Recent studies have highlighted the importance of SRP19 in regulating the assembly and stability of the SRP complex, impacting the efficiency of protein translation and membrane integration. Given its pivotal function, SRP19 has become a focal point for understanding the molecular mechanisms underlying protein trafficking and its implications in diseases associated with protein misfolding and transport dysfunction. Furthermore, the exploration of SRP19 as a potential therapeutic target opens new avenues in drug development for conditions stemming from cellular transport anomalies. As a recombinant protein, SRP19 can be utilized in structural and functional studies to elucidate its interaction with other SRP components and to investigate its role in various cellular contexts, thereby providing deeper insights into the SRP pathway and its regulation.
