Analytical Data
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基因名
RAD1
- Application
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别名
DNA repair exonuclease rad1 homolog Rad1-like DNA damage checkpoint protein
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60671
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表达区间
1-282aa
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分子量
58.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAD1 (Recombination Activation 1) is a key protein involved in DNA damage response and repair mechanisms, playing a critical role in maintaining genomic stability. It is part of the RAD1-RAD9-HUS1 complex, known as the 911 complex, which is essential for the cellular response to double-strand breaks and other forms of DNA damage. The RAD1 protein aids in the activation of cell cycle checkpoints, ensuring proper DNA repair processes before cell division. Research has shown that alterations in RAD1 function can lead to increased sensitivity to genotoxic agents and a higher likelihood of developing cancer, as it compromises the integrity of the DNA repair machinery. Additionally, RAD1 has been implicated in various cellular processes beyond DNA repair, including apoptosis and the regulation of gene expression. Understanding the structure, function, and regulatory mechanisms of RAD1 and its interactions within the broader context of the DNA damage response network is crucial for developing potential therapeutic strategies aimed at enhancing DNA repair in cancer cells or sensitize them to radiotherapy and chemotherapy. Advances in biochemistry and molecular biology techniques have allowed for the detailed study of RAD1's role in these processes, contributing to a more comprehensive understanding of its implications in human health and disease. Ongoing research aims to elucidate the precise molecular pathways involving RAD1, offering insights into potential interventions for diseases linked to DNA repair deficiencies.
