Analytical Data
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基因名
MPV17
- Application
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别名
Glomerulosclerosis; Mpv17; Mpv17 human homolog of glomerulosclerosis and nephrotic syndrome; MpV17 mitochondrial inner membrane protein; MPV17_HUMAN; MTDPS6; Protein Mpv17; SYM1
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P39210
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表达区间
1-176aa
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分子量
35.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MPV17 is a mitochondrial inner membrane protein that has gained significant attention in the field of molecular biology due to its association with various mitochondrial dysfunctions and genetic disorders. Initially identified in studies related to hepatocerebral mitochondrial DNA depletion syndrome (MDDS), MPV17 is crucial for maintaining mitochondrial integrity and function. Research has shown that mutations in the MPV17 gene can lead to severe clinical manifestations, including neurological deficits and liver abnormalities, which highlight its vital role in cellular energy metabolism and mitochondrial homeostasis. The understanding of MPV17's structure and function is essential not only for elucidating the mechanisms underlying mitochondrial diseases but also for developing potential therapeutic strategies. Investigations into MPV17 have focused on its interactions with other mitochondrial proteins, its involvement in nucleotide metabolism, and the signaling pathways that regulate its activity. Given the increasing prevalence of mitochondrial disorders, exploring the biological significance of MPV17 and its potential as a biomarker or therapeutic target represents a promising avenue for future research in mitochondrial genetics and therapy.
