Analytical Data
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基因名
CCR8
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简介
CCR8 Protein-VLP, a receptor for CCL1/SCYA1/I-309, may regulate monocyte chemotaxis and thymic cell line apoptosis. It also acts as an alternative coreceptor with CD4 for HIV-1 infection, facilitating viral entry. The interaction with CCL1 highlights its role in mediating cellular responses to this chemokine, implying a regulatory function in immune and inflammatory processes. CCR8 Protein, Human (P. pastoris, His) is the recombinant human-derived CCR8 protein, expressed by P. pastoris , with C-Myc, C-6*His labeled tag.
- Application
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种属
Human
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表达系统
P. pastoris
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标签
C-Myc;C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51685
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表达区间
M1-K35
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蛋白长度
Extracellular Domain
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCR8 (C-C chemokine receptor type 8) is a chemokine receptor that plays a significant role in immune system regulation, particularly in the migration and activation of various immune cell types, including T-cells and regulatory T-cells. Its involvement in immune responses makes it a relevant target for studying diseases such as asthma, autoimmune disorders, and cancer. CCR8 is known to bind specific chemokines, thereby influencing the recruitment of immune cells to sites of inflammation. Understanding the structure and function of CCR8 is critical for developing therapeutic strategies aimed at modulating immune responses. Recent advances in recombinant protein technology have enabled researchers to produce and study CCR8 as a recombinant protein, allowing for detailed investigations of its binding properties, signaling pathways, and potential as a drug target. The recombinant CCR8 protein can be utilized in various assays to explore its interactions with ligands and inhibitors, which is instrumental in drug discovery processes. Additionally, as CCR8 is expressed on certain tumor-infiltrating lymphocytes, studying its role may provide insights into the tumor microenvironment and aid in the development of immunotherapies. Overall, research on CCR8 and its recombinant variants holds promise for advancing our understanding of immune regulation and developing novel treatments for immune-related diseases.
