Analytical Data
-
Gene name
CALCB
- Application
-
Alternative Names
Beta-type CGRP
-
Species
Human
-
Source
E. coli
-
Tag
N- GST
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P10092
-
Expression Region
1-127aa
-
Molecular Weight
40.7 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CALCB (Calcitonin Gene-Related Peptide Beta) is a neuropeptide that plays a significant role in various physiological processes, including pain modulation, neurogenic inflammation, and vascular regulation. Its importance in the central and peripheral nervous systems has prompted extensive research into its structure and function, particularly in the context of diseases such as migraine, where elevated levels of CALCB are observed. Researchers are particularly interested in the recombinant production of CALCB to facilitate detailed studies on its biological activity and therapeutic potential. Recombinant proteins allow for the generation of large quantities of pure CALCB, which is essential for characterizing its interactions with specific receptors and elucidating its signaling pathways. This has implications not only for understanding pain mechanisms but also for the development of novel therapeutic strategies targeting CALCB-related pathways. Moreover, the investigation of CALCB’s role in pathological conditions could lead to breakthroughs in treating conditions such as cardiovascular diseases, where its vasodilatory effects and involvement in homeostasis are crucial. Consequently, the recombinant expression of CALCB serves as a vital tool in both basic research and clinical applications, ultimately advancing our understanding of this important neuropeptide and its potential as a therapeutic target.
