Analytical Data
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Gene name
COA1
- Application
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Alternative Names
Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15KDA
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9GZY4
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Expression Region
38-146aa
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Molecular Weight
39.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
COA1 (Cofactor of ARF1) is a critical protein that plays a significant role in the endosomal-lysosomal pathway, particularly in the regulation of cargo sorting and membrane trafficking. It has emerged as a vital factor in the cellular mechanisms of organelle morphology and function, especially in mitochondria. Research has shown that COA1 is involved in maintaining mitochondrial integrity and is essential for mitochondrial protein import, linking it to various cellular processes such as metabolism, apoptosis, and oxidative stress response. Deficiency or malfunction of COA1 has been implicated in several diseases, including neurodegenerative disorders and metabolic syndrome, highlighting its potential as a therapeutic target. The recombinant production of COA1 protein enables detailed studies on its structural and functional properties, facilitating the exploration of its interactions with other proteins and lipids within the cellular environment. This research is pivotal for understanding the molecular underpinnings of COA1's role in health and disease, paving the way for the development of novel therapeutic strategies aimed at modulating its activity in various pathological conditions. The ongoing investigations into COA1 not only enhance our understanding of intracellular trafficking but also contribute to the broader field of mitochondrial biology, emphasizing the importance of this protein in cellular homeostasis and its potential in drug discovery.
