Analytical Data
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基因名
AVPR2
- Application
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别名
V2R Alternative name(s): AVPR V2 Antidiuretic hormone receptor Renal-type arginine vasopressin receptor
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种属
Pig
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P32307
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表达区间
292-370aa
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分子量
24.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AVPR2, or arginine vasopressin receptor 2, is a G-protein coupled receptor (GPCR) that plays a crucial role in regulating water reabsorption in the kidneys, influencing blood pressure and osmotic balance. Mutations in the AVPR2 gene can lead to nephrogenic diabetes insipidus (NDI), a condition characterized by an inability to concentrate urine, resulting in excessive urination and thirst. Research on AVPR2 recombinant proteins has gained attention for its potential to elucidate the receptor's signaling mechanisms and facilitate drug development targeting related disorders. Understanding AVPR2's structure and function at a molecular level can help identify therapeutic interventions for conditions associated with defective vasopressin action. The study of AVPR2 also extends to investigating its role in various physiological processes, such as social behavior and stress response. As GPCRs are significant drug targets, engineering AVPR2 recombinant proteins can enhance our comprehension of receptor pharmacology and aid in the discovery of more effective medications. This understanding is critical not only for treating NDI but also for broader applications in cognitive and behavioral health, thus highlighting the importance of continued research in this area.
