Analytical Data
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基因名
ATPAF2
- Application
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别名
ATP12 homolog
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N5M1
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表达区间
41-289aa
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分子量
32.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATPAF2 (ATP synthase assembly factor 2) is a critical protein involved in the assembly and stability of mitochondrial ATP synthase, the enzyme responsible for ATP production through oxidative phosphorylation. Dysfunction of ATP synthase can lead to a variety of mitochondrial diseases and has been implicated in age-related degenerative disorders, making ATPAF2 a significant focus of research in cellular bioenergetics. It was first identified as a key player in the assembly of ATP synthase, highlighting its essential role in maintaining proper mitochondrial function. Studies have demonstrated that ATPAF2 interacts with several mitochondrial proteins, influencing the assembly and activity of ATP synthase complexes. Given its pivotal role in energy metabolism, understanding the precise function and regulation of ATPAF2 is crucial for elucidating the mechanisms underlying mitochondrial diseases. Recent research efforts aim to explore the therapeutic potential of modulating ATPAF2 activity or its pathways to develop novel treatments for mitochondrial-related disorders. By dissecting the molecular mechanisms by which ATPAF2 aids in ATP synthase assembly, researchers hope to uncover targets for drug development, ultimately seeking to mitigate the impact of mitochondrial dysfunction on human health.
