Analytical Data
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基因名
Nectin-2/CD112
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简介
Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.
- Application
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别名
CD112; MPH; Nectin2; PRR2; PVRL2; HVEB; PVRR2
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92692-2
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表达区间
Q32-L360
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蛋白长度
Extracellular Domain
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分子量
45-52 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Nectin-2, also known as CD112, is a member of the Nectin family of immunoglobulin-like cell adhesion molecules that play a crucial role in neuronal development and immune responses. As a ligand for the immune receptor DNAM-1 and associated with the activation of natural killer (NK) cells and CD8+ T cells, Nectin-2 facilitates not only cellular adhesion but also the modulation of immune responses against tumors and infections. Recent studies have highlighted its significance in the tumor microenvironment, where it can influence tumor progression and immune evasion. The recombinant production of Nectin-2/CD112 protein has garnered interest due to its potential applications in immunotherapy, especially in enhancing anti-tumor immunity. By creating an immunogenic environment, Nectin-2 holds promise as a therapeutic target for various malignancies. Moreover, understanding its structure and functional dynamics could lead to the development of novel immune modulators. As researchers explore the applications of Nectin-2 in cancer therapy, its interaction with immune cells offers valuable insights into designing strategies for improving immune checkpoint blockade and combination therapies. Thus, the study and production of recombinant Nectin-2/CD112 proteins are pivotal in advancing cancer immunotherapy and elucidating the intricate interplay between tumor cells and the immune system.
