Analytical Data
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基因名
EMC4
- Application
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别名
Cell proliferation-inducing gene 17 protein (Transmembrane protein 85) (TMEM85)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5J8M3
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表达区间
2-183aa
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分子量
26.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EMC4, a member of the endoplasmic reticulum membrane protein complex (EMC), plays a crucial role in the biogenesis of membrane proteins. The EMC complex facilitates the insertion and folding of hydrophobic membrane proteins into the endoplasmic reticulum (ER), which is essential for maintaining cellular homeostasis and facilitating proper signal transduction. Research into EMC4 has gained traction due to its potential implications in various diseases, including neurodegenerative disorders and cancers, where membrane protein misfolding and aggregation can disrupt cellular functions. Recent studies have highlighted the structure and functional dynamics of EMC4, revealing its interactions with different substrates and other molecular chaperones in the ER. Understanding the mechanisms by which EMC4 assists in membrane protein assembly not only enhances our fundamental knowledge of protein biology but also opens avenues for therapeutic interventions targeting diseases associated with protein misfolding. Consequently, EMC4 represents a significant focus for researchers aiming to elucidate the complexities of protein synthesis, folding, and quality control within the cell, ultimately contributing to the development of strategies to combat related pathologies.
