Analytical Data
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Gene name
CSE1L
- Application
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Alternative Names
Cellular apoptosis susceptibility protein Chromosome segregation 1-like protein Importin-alpha re-exporter
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P55060
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Expression Region
1-200aa
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Molecular Weight
39.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSE1L, or Chromosome Segregation 1-Like, is a protein that plays a vital role in cellular processes, particularly in the regulation of nucleocytoplasmic transport and cell cycle progression. Research into CSE1L has garnered attention due to its implications in various biological processes, including cell division and the maintenance of genomic stability. Studies have shown that CSE1L is involved in the transport of essential proteins and RNA molecules between the nucleus and the cytoplasm, a function crucial for cellular function and homeostasis. Aberrations in CSE1L expression or function have been linked to several diseases, including cancer, wherein altered nucleocytoplasmic transport can lead to the mismanagement of oncoproteins and tumor suppressors. Understanding the structure and function of CSE1L through recombinant protein studies is significant for elucidating its mechanisms in cellular biology and its potential as a therapeutic target. Continued research on CSE1L not only aims to uncover its role in fundamental cellular processes but also seeks to explore its relevance in disease contexts, opening avenues for targeted drug development that could mitigate the effects of its dysregulation.
