Analytical Data
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Gene name
KGF-2/FGF-10
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简介
KGF-2/FGF-10 Protein is vital in regulating embryonic development, crucial for cell proliferation, differentiation, and normal branching morphogenesis. Essential for organ and tissue development, it interacts with FGFR1 and FGFR2, integral to its signaling. The protein may contribute to wound healing and engages with FGFBP1, indicating regulatory interactions within FGF signaling pathways. KGF-2/FGF-10 Protein, Rat is the recombinant rat-derived KGF-2/FGF-10 protein, expressed by E. coli , with tag free.
- Application
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Biological Activity
Measured in a cell proliferation assay using 4MBr-5 rhesus monkey epithelial cells. The ED50 for this effect is 98.78 ng/mL, corresponding to a specific activity is 1.01×10^4 units/mg. Measured in a cell proliferation assay using 4MBr-5 rhesus monkey epithelial cells. The ED50 for this effect is 98.78 ng/mL, corresponding to a specific activity is 1.01×10^4 units/mg.
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Alternative Names
rMuFGF-10; Fibroblast growth factor 10; Fgf10
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Species
Rat
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Uniprot
P70492
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Expression Region
Q37-S215
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Protein Length
Partial
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Molecular Weight
23 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KGF-2 (Keratinocyte Growth Factor-2) and FGF-10 (Fibroblast Growth Factor-10) are members of the FGF family that play critical roles in various biological processes, including cell proliferation, differentiation, and tissue repair. These growth factors are particularly important in epithelial and mesenchymal interactions, influencing skin, lung, and gastrointestinal development. KGF-2 has been shown to stimulate keratinocyte proliferation and migration, making it vital for wound healing and tissue regeneration. FGF-10, on the other hand, is involved in the development of multiple organ systems and is essential for maintaining epithelial integrity. Recent studies have highlighted the therapeutic potential of KGF-2/FGF-10 recombinant proteins in regenerative medicine, particularly in treatments for skin injuries, respiratory diseases, and gastrointestinal disorders. Their ability to enhance cellular responses and promote healing mechanisms makes them promising candidates for developing novel therapies. The ongoing research focuses on optimizing the production methods of these recombinant proteins and elucidating their mechanisms of action, which could lead to advanced treatment options for a variety of conditions characterized by tissue damage or impaired regeneration. Understanding the synergistic effects of KGF-2 and FGF-10 in tissue repair could pave the way for innovative regenerative strategies that leverage their unique biological properties to improve patient outcomes.
