Analytical Data
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Gene name
Contactin-1/CNTN1
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简介
Contactin-1/CNTN1 protein mediates surface interactions during nervous system development. It forms paranodal axo-glial junctions in peripheral nerves and facilitates axon-glia signaling through CNTNAP1. It acts as a ligand for NOTCH1, promoting NOTCH1 activation. Contactin-1/CNTN1 also interacts with TNR, inhibiting neurite outgrowth. It binds to CNTNAP1 and PTPRZ1, and forms a complex with NRCAM, PTPRB, and TASOR. Contactin-1/CNTN1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Contactin-1/CNTN1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
CNTN1; Contactin1; F11; F3; Neural cell surface protein F3
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P12960
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Expression Region
M1-L1000
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Protein Length
Partial
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Molecular Weight
110-120 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Contactin-1 (CNTN1) is a member of the immunoglobulin superfamily and plays a crucial role in the development and maintenance of the nervous system, particularly in the formation of axonal connections and myelination. It is predominantly expressed in the nervous system, where it interacts with various cellular partners, including neurofascin and Caspr, to facilitate cell adhesion and promote the clustering of ion channels at juxtaparanodal domains. Abnormalities in CNTN1 expression or function have been implicated in several neurological disorders, such as multiple sclerosis and neuropathies, highlighting its importance in neurobiology. The recombinant protein of CNTN1 is particularly valuable for research purposes, as it allows scientists to investigate its structural and functional properties in vitro and in vivo. By studying the interactions of CNTN1 with its binding partners, researchers can elucidate the mechanisms underlying neuronal connectivity and myelination. Furthermore, the use of CNTN1 recombinant protein can aid in developing therapeutic strategies for neurodegenerative diseases and peripheral nerve injuries by promoting nerve repair and regeneration. Overall, the exploration of CNTN1 through recombinant protein studies provides significant insights into neural cell interactions, neurodevelopment, and potential clinical applications in neurology.
