Analytical Data
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基因名
COL21A1
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简介
COL21A1 Protein is a member of the fibre-associated collagen interrupt helix (FACIT) family. COL21A1 Protein is a secreted protein widely present in a variety of tissues. COL21A1 Protein may contribute to the extracellular matrix assembly of vascular networks during angiogenesis. COL21A1 Protein, Human (HEK293, His) is the recombinant human-derived COL21A1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
rHuCollagen alpha-1(XXI) chain/COL21A1, His ; COL21A1; collagen, type XXI, alpha 1; collagen alpha-1(XXI) chain; alpha 1 type XXI collagen; FP633; COLA1L; dJ708F5.1; dJ682J15.1; FLJ39125; FLJ44623; MGC26619; DKFZp564B052
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96P44-1
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表达区间
E23-Y957
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氨基酸序列
EDGEVRSSCRTAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDSGEHLTAAVESILYLGGNTKTGKAIQFALDYLFAKSSRFLTKIAVVLTDGKSQDDVKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFYVEDYIAISKIREVMKQKLCEESVCPTRIPVAARDERGFDILLGLDVNKKVKKRIQLSPKKIKGYEVTSKVDLSELTSNVFPEGLPPSYVFVSTQRFKVKKIWDLWRILTIDGRPQIAVTLNGVDKILLFTTTSVINGSQVVTFANPQVKTLFDEGWHQIRLLVTEQDVTLYIDDQQIENKPLHPVLGILINGQTQIGKYSGKEETVQFDVQKLRIYCDPEQNNRETACEIPGFNGECLNGPSDVGSTPAPCICPPGKPGLQGPKGDPGLPGNPGYPGQPGQDGKPGYQGIAGTPGVPGSPGIQGARGLPGYKGEPGRDGDKGDRGLPGFPGLHGMPGSKGEMGAKGDKGSPGFYGKKGAKGEKGNAGFPGLPGPAGEPGRHGKDGLMGSPGFKGEAGSPGAPGQDGTRGEPGIPGFPGNRGLMGQKGEIGPPGQQGKKGAPGMPGLMGSNGSPGQPGTPGSKGSKGEPGIQGMPGASGLKGEPGATGSPGEPGYMGLPGIQGKKGDKGNQGEKGIQGQKGENGRQGIPGQQGIQGHHGAKGERGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQVCTDVIRAQLPVLLQSGRIRNCDHCLSQHGSPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGYPGEQGPPGPPGPEGPPGISKEGPPGDPGLPGKDGDHGKPGIQGQPGPPGICDPSLCFSVIARRDPFRKGPNY
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
115-125 kDa & 220 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COL21A1, or Collagen Type XXI Alpha 1, is a member of the collagen family with significant implications in connective tissue development and homeostasis. Its expression is primarily noted in various tissues, including skin, cartilage, and the central nervous system. Research has increasingly focused on COL21A1 due to its emerging role in various physiological processes and diseases, such as fibrosis, cancer, and developmental disorders. The recombinant form of COL21A1 protein is crucial for elucidating its functional properties and interactions with other extracellular matrix components. In vitro studies utilizing recombinant COL21A1 facilitate the investigation of its structural characteristics, binding affinities, and biological effects on cell behavior, paving the way for potential therapeutic applications. The characterization of this protein is vital for understanding its role in tissue architecture and integrity, as well as its involvement in pathological conditions. Moreover, exploring the molecular mechanisms underlying COL21A1's function can contribute to the development of innovative strategies for treating diseases linked to extracellular matrix dysregulation. Overall, the study of recombinant COL21A1 protein represents a promising frontier in biomedical research, aiming to unlock new insights into collagen-related disorders and enhance therapeutic interventions.
