Analytical Data
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基因名
UPP1
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简介
UPP1 protein is a key member of the PNP/UDP phosphorylase family and plays an important role in cellular processes, especially nucleotide metabolism. UPP1 shares conserved features with related proteins and is involved in phosphorylase activity. UPP1 Protein, Human (His) is the recombinant human-derived UPP1 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
UPP1 Protein; Uridine Phosphorylase 1; UPP1
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86Y75
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表达区间
M1-A173
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蛋白长度
Full Length
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UPP1, or uridine phosphorylase 1, is an enzyme that plays a crucial role in nucleoside metabolism, specifically in the salvage pathway of uridine recycling. Its primary function is to catalyze the phosphorolytic cleavage of uridine, producing uracil and ribose-1-phosphate, which are vital for nucleotide synthesis and cellular energy metabolism. Research on UPP1 has gained significant interest due to its potential implications in various physiological and pathological processes, including cancer, neurodegenerative diseases, and metabolic disorders. Understanding the structure and function of UPP1 is essential for identifying therapeutic targets and developing inhibitors that could modulate its activity for clinical benefits. Recombinant UPP1 protein expression and purification have become key approaches in studying this enzyme's biochemical properties, substrate specificity, and regulatory mechanisms. By utilizing advanced techniques such as molecular cloning, expression in bacterial or eukaryotic systems, and subsequent characterization through assays and structural biology methods, researchers aim to gain insights into UPP1's role in health and disease. Additionally, elucidating the enzyme's interactions with other biomolecules can provide deeper knowledge of its biological significance and therapeutic potential. In summary, UPP1 represents a promising target for drug discovery and therapeutic interventions, making its recombinant protein research a vital area of investigation in the field of biochemistry and molecular biology.
