Analytical Data
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Gene name
TIMM8B
- Application
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Alternative Names
TIM8B; DDP2; DDPL; DDP-like protein; Deafness dystonia protein 2; Mitochondrial import inner membrane translocase subunit Tim8 B
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5J9
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Expression Region
Ala2~Gln83
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Molecular Weight
14kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIMM8B (Translocase of Inner Mitochondrial Membrane 8B) is a key protein involved in the proper functioning of mitochondria, the cell's energy-producing organelles. Research on TIMM8B has gained momentum due to its crucial role in mitochondrial protein import and its implications in various human diseases. Deficiencies or mutations in TIMM8B have been linked to syndromes characterized by neurological and developmental defects, especially affecting the auditory system. Moreover, the study of TIMM8B offers insights into the mechanisms of mitochondrial dysfunction, which is a common feature in numerous pathologies, including metabolic disorders and neurodegenerative diseases. Understanding the structure and function of TIMM8B through recombinant protein studies may provide valuable information for developing therapeutic approaches targeting mitochondrial-related diseases. Recent advancements in recombinant DNA technology have allowed scientists to produce and characterize TIMM8B in vitro, facilitating deeper exploration of its molecular interactions and functional dynamics within mitochondrial biogenesis. This research could potentially lead to novel strategies for the prevention and treatment of conditions associated with mitochondrial dysfunction, highlighting the importance of TIMM8B in both basic and applied biomedical research.
